Table 1.

Altered cartilage permeability during osteoarthritis (OA).

Altered cartilage permeability	Events related to OA	References
Causes	Increased protease activity	[25]
	Increased subchondral vessels invading calcified cartilage	[27]
	Joint immobilization	[22]
Consequences	Loss of matrix components in the joint space	[10]
	Access of deleterious agents (toxins, immunoglobulins)	[10]
	Access of proinflammatory plasma proteins	[26]