Table 1.
Characteristics of the population at baseline and details of current coronary event and intervention.
| Ivabradine n=82 |
Placebo n=42 |
p | |
|---|---|---|---|
| Demographic characteristics | |||
| Age (years) | 60.1±10.8 | 58.0±11.6 | 0.2971 |
| Men, n (%) | 64 (78%) | 33 (79%) | 0.9468 |
| Weight (kg) | 77.9±13.1 | 80.5±13.0 | 0.2979 |
| Body mass index (kg/m2) | 27.0±3.5 | 27.6±3.5 | 0.3385 |
| Smoking habits | |||
| Nonsmoker, n (%) | 27 (33%) | 10 (24%) | |
| Ex-smoker, n (%) | 24 (29%) | 15 (36%) | |
| Smoker, n (%) | 31 (38%) | 17 (41%) | 0.5510 |
| Cardiac parameters | |||
| Heart rate (bpm) | 88.0±10.0 | 87.4±8.0 | 0.7689 |
| Systolic blood pressure (mm Hg) | 122.8±22.1 | 132.0±22.0 | 0.4258 |
| Diastolic blood pressure (mm Hg) | 78.4±12.1 | 78.9±14.0 | 0.9989 |
| Medical history | |||
| Previous myocardial infarction, n (%) | 8 (10%) | 1 (2%) | 0.1341 |
| Previous PTCA, n (%) | 5 (6%) | 4 (10%) | 0.4864 |
| Lipid metabolism disorders, n (%) | 31 (38%) | 21 (50 %) | 0.1508 |
| Diabetes mellitus, n (%) | 13 (16%) | 10 (24%) | 0.2887 |
| Hypertension, n (%) | 33 (40%) | 26 (62%) | 0.223 |
| Details of current coronary event | |||
| Angioplasty with at least one stent, n (%) | 78 (95%) | 41 (98%) | 0.5035 |
| Patients with single-vessel disease, n (%) | 51 (62%) | 26 (62%) | 0.4864 |
| Patient with two-vessel disease, n (%) | 20 (24%) | 8 (19%) | |
| Patients with three-vessel disease, n (%) | 11 (13%) | 8 (19%) | 0.6292 |
| Patients with left main coronary disease, n (%) | 3 (4%) | 2 (5%) | 0.7675 |
| Time between STEMI and PCI Median (Q1;Q3) |
209.0 (140.0;270.0) | 186.5 (140.0;290.0) | 0.6489 |
| Time between STEMI and PCI Median (Q1;Q3) |
87.5 (64.0;130.0) | 113.0 (91.0;132.0) | 0.1052 |
| Concomitant treatments | |||
| Beta-blockers | |||
| At infusion | 22 (27%) | 18 (43%) | 0.1978 |
| After infusion | 71 (87%) | 32 (76%) | 0.1441 |
| Nitrates | |||
| At infusion | 48 (59%) | 25 (60 %) | 0.8817 |
| After infusion | 32 (39%) | 12 (29%) | 0.2496 |
| Antithrombotic agents | |||
| At infusion | 75 (92%) | 38 (91%) | 0.717 |
| After infusion | 78 (95%) | 36 (86%) | 0.686 |
| RAS inhibitors | |||
| At infusion | 46 (56%) | 22 (52%) | 0.6939 |
| After infusion | 61 (74%) | 30 (71%) | 0.7240 |
| Lipid-lowering agents | |||
| At infusion | 52 (63%) | 25 (60%) | 0.4974 |
| After infusion | 42 (51%) | 28 (67%) | 0.1006 |
PCI: percutaneous coronary intervention; PTCA: percutaneous transluminal coronary angioplasty; RAS: renin-angiotensin system; STEMI: ST-segment elevation myocardial infarction.