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. Author manuscript; available in PMC: 2013 Nov 9.
Published in final edited form as: Psychopharmacology (Berl). 2012 Apr 20;226(4):10.1007/s00213-012-2716-y. doi: 10.1007/s00213-012-2716-y

Fig. 2.

Fig. 2

Effect of nor-BNI on nicotine-primed reinstatement of nicotine-CPP. Mice conditioned with 0.5 mg/kg nicotine (s.c.) expressed a significant CPP on test day (TD). Significant CPP is present on extinction day 1 (ED1), but is extinguished by day 3 (ED3). On day 8, nicotine-CPP is reinstated by nicotine (RS V/N) (0.1 mg/kg, s.c.) and is not blocked by nor-BNI (RS NB/N) (10 mg/kg, s.c.). Nor-BNI pretreatment had no significant effect on reinstatement of CPP (RS NB/V). Each point represents the mean±SEM of seven to nine mice per group (n=5 per group for RS NB/N, n=4 per group for RS NB/V). *p <0.05 vs. the corresponding saline group