Fig. 3.

Effect of nor-BNI on stress-induced reinstatement of CPP. Mice conditioned with 0.5 mg/kg nicotine (s.c.) expressed a robust CPP on test day (TD) and were exposed to the FST to induce stress after three extinction days (ED3). Stress induced a significant reinstatement of nicotine-CPP in vehicle (Veh/FST) pretreated mice, but not in nor-BNI pretreated mice (nor-BNI/FST). A significant CPP was not expressed in vehicle-treated unstressed mice. Nor-BNI had no significant effect on CPP in unstressed mice. Each point represents the mean±SEM of six to eight mice per group. *p<0.05 vs. the corresponding saline/unstressed and nor-BNI-treated groups