Table 1.
Effects of LC (0.5-5 mM) on LVEDP, LVDP, HR, RPP and CFR in the control and treated isolated rat hearts during pre-reperfusion and 120 min reperfusion in protocol 1. Data are expressed as Mean±SEM
| Group | Factor | Pre-Rep | Reperfusion |
||||||
|---|---|---|---|---|---|---|---|---|---|
| 5 min | 15 min | 30 min | 45 min | 60 min | 90 min | 120 min | |||
| Control | LVEDP | 8.9±1.8 | 18.1±2.8*** | 14.7±2.0** | 13.4±2.0* | 11.9±1.8 | 10.4±2.0 | 6.5±1.0 | 5.5±0.9 |
| LVDP | 100±16 | 117±16 | 115±13 | 108±10 | 104±14 | 100±10 | 90±12 | 80±13 | |
| H R | 224±15 | 240±23 | 224±16 | 219±17 | 244±17 | 220±17 | 227±16 | 190±13 | |
| RPP | 22319±1904 | 27697±2870 | 2522``4±1816 | 23384±1836 | 25525±2277 | 21250±1910 | 20619±2032 | 15054±1133* | |
| CFR | 4.9±0.6 | 7.4±0.5* | 6.6±0.5 | 5.6±0.5 | 5.1±0.5 | 4.6±0.5 | 4.2±0.5 | 3.9±0.7 | |
| LC (0.5 mM) |
LVEDP | 8.4±2 | 8.5±3.1 | 8.0±1.7 | 8.3±2.0 | 6.0±1.5 | 5.3±2.0 | 4.2±0.9* | 3.4±0.9* |
| LVDP | 83±12 | 114±13* | 117±8* | 112±9* | 100±10 | 95±9 | 89±14 | 82±10 | |
| H R | 214±21 | 263±14* | 239±17 | 240±24 | 239±20 | 230±20 | 212±20 | 196±17 | |
| RPP | 17497±3141 | 29888±2639** | 27857±1701** | 26597±2205** | 23978±2724* | 22111±2341 | 19037±2376 | 16511±2185 | |
| CFR | 3.5±0.4 | 6.1±0.6* | 5.6±0.5 | 5.2±0.5 | 4.8±0.5 | 4.2±0.5 | 4.0±0.3 | 3.5±0.3 | |
| LC (2.5 mM) |
LVEDP | 6.6±0.9 | 7.5±0.9 | 7.3±0.6 | 4.3±0.9 | 4.3±1.2 | 3.3±0.9 | 1.8±0.3* | 2.0±0.4* |
| LVDP | 95±9 | 127±10* | 122±9* | 124±11* | 112±12 | 114±11 | 97±11 | 83±9 | |
| H R | 223±25 | 251±27 | 259±23 | 243±21 | 245±26 | 243±21 | 238±19 | 232±15 | |
| RPP | 21205±2591 | 31601±3217** | 31677±3186** | 29347±3039** | 27263±2923* | 25321±3147 | 23291±2658 | 19119±1368 | |
| CFR | 3.9±0.4 | 6.6±0.4* | 5.8±0.3 | 5.7±0.4 | 5.1±0.4 | 4.7±0.4 | 4.5±0.3 | 4.3±0.5 | |
| LC (5 mM) |
LVEDP | 8.6±1.3 | 11.4±3.1 | 10.5±2.0 | 9.9±2.8 | 8.8±2.2 | 7.8±1.3 | 5.1±1.0* | 4.8±1.1* |
| LVDP | 92±9 | 139±16 ** | 133±9 ** | 120±9* | 114±14 | 105±10 | 96±14 | 88±9 | |
| H R | 209±22 | 221±17 | 240±9 | 234±14 | 242±12 | 215±16 | 186±13 | 186±16 | |
| RPP | 18476±1251 | 31093±265*** | 31859±1060*** | 27974±1877** | 26563±1113** | 21506±1389 | 17583±1163 | 16558±1673 | |
| CFR | 4.6±0.7 | 7.1±0.9* | 6.3±0.9 | 5.7±0.8 | 5.7±1.2 | 5.1±0.9 | 4.1±0.8 | 3.9±0.9 | |
*** P<0.001, ** P<0.01,* P<0.05 versus pre-reperfusion value by using repeated ANOVA with LSD post test. n=6-8 in each group. LC; L-carnitine, LVEDP; left ventricular end diastolic pressure (mmHg), LVDP; left ventricular developed pressure (mmHg), HR; heart rate (beats/min), RPP; rate pressure product (mmHg.beats.min-1), CFR; coronary flow rate (ml/min), Pre-Rep; Pre-reperfusion time