Table 2.
Effects of ETM (1µM) with or without LC (2.5 mM) on LVEDP, LVDP, HR, RPP and CFR in the control and treated isolated rat hearts during pre-reperfusion and 120 min reperfusion in protocol 1. Data are expressed as Mean±SEM
| Group | Factor | Pre-Rep | Reperfusion |
||||||
|---|---|---|---|---|---|---|---|---|---|
| 5 min | 15 min | 30 min | 45 min | 60 min | 90 min | 120 min | |||
| ETM (1 µM) |
LVEDP | 9.3±1.4 | 13.0±1.6* | 13.3±0.7* | 14.0±0.6* | 11.0±1.0 | 10.0±1.2 | 8.3±1.7 | 6.0±1.5 |
| LVDP | 123±10 | 131±10 | 130±9 | 130±10 | 127±9 | 126±9 | 122±9 | 121±9 | |
| H R | 241±37 | 221±42 | 238±29 | 245±21 | 224±31 | 200±27 | 191±36* | 166±39** | |
| RPP | 29418±3949 | 28678±5081 | 30735±3261 | 31760±1973 | 28241±3398 | 24983±3059 | 23071±4081* | 19923±4473** | |
| CFR | 2.9±0.6 | 4.4±0.4 | 3.9±0.5 | 3.4±0.4 | 2.9±0.4 | 2.5±0.4 | 2.0±0.4 | 1.8±0.4 | |
| LC (2.5 mM) + ETM (1 µM) | LVEDP | 12.4±1.9 | 17.5±4.3** | 19.0±5.1** | 20.0±4.8** | 18.6±4.5** | 16.0±3.7* | 14.4±3.9 | 12.6±4.4 |
| LVDP | 116±11 | 130±10 | 129±11 | 127±12 | 128±13 | 126±14 | 122±13 | 120±12 | |
| H R | 170±25 | 160±24 | 138±33 | 134±40 | 130±37 | 113±41* | 107±53** | 96±56 ** | |
| RPP | 16458±3083 | 20937±3498 | 18037±4679 | 17420±5644 | 19005±5194 | 14572±5313 | 13075±6440 | 11737±6888 | |
| CFR | 2.6±0.9 | 4.4±0.9 | 4.2±0.9 | 3.0±.0.9 | 2.6±0.9 | 2.2±0.9 | 1.7±0.8 | 1.5±0.7 | |
** P<0.01, * P<0.05 versus pre-reperfusion value by using repeated ANOVA with LSD post test. n=6-8 in each group