Table 4.
Effects of LC (0.5-5 mM) on LVEDP, LVDP, HR, RPP and CFR in the control and treated isolated rat hearts during pre-reperfusion and 120 min reperfusion in protocol 3. Data are expressed as Mean±SEM
| Group | Factor | Pre-Rep | Reperfusion |
||||||
|---|---|---|---|---|---|---|---|---|---|
| 5 min | 15 min | 30 min | 45 min | 60 min | 90 min | 120 min | |||
| Control | LVEDP | 8.9±1.8 | 18.1±2.8*** | 14.7±2.0** | 13.4±2.0* | 11.9±1.8 | 10.4±2.0 | 6.5±1.0 | 5.5±0.9 |
| LVDP | 100±16 | 117±16 | 115±13 | 108±10 | 104±14 | 100±10 | 90±12 | 80±13 | |
| H R | 224±15 | 240±23 | 224±16 | 219±17 | 244±17 | 220±17 | 227±16 | 190±13 | |
| RPP | 22319±1904 | 27697±2870 | 25224±1816 | 23384±1836 | 25525±2277 | 21250±1910 | 20619±2032 | 15054±1133* | |
| CFR | 4.9±0.6 | 7.4±0.5* | 6.6±0.5 | 5.6±0.5 | 5.1±0.5 | 4.6±0.5 | 4.2±0.5 | 3.9±0.7 | |
| LC (0.5 mM) |
LVEDP | 4.4±0.7 | 7.2±1.8 | 6.4±1.6 | 5.6±1.1 | 7.0±3.2 | 5.3±2.3 | 3.7±1.7 | 3.7±1.1 |
| LVDP | 102±16 | 124±13 | 120±10 | 116±11 | 117±12 | 109±14 | 96±17 | 92±17 | |
| H R | 219±22 | 212±43 | 225±23 | 229±11 | 211±9 | 208±10 | 178±26 | 158±18* | |
| RPP | 22595±3431 | 26038±5197 | 27140±2552 | 26499±1396 | 24451±2027 | 22407±2478 | 16837±4264 | 14635±3507** | |
| CFR | 4.4±0.7 | 6.6±0.6 | 6.5±0.8 | 5.7±0.8 | 5.3±1.0 | 4.8±1.0 | 4.3±1.0 | 4.0±1.1 | |
| LC (2.5 mM) |
LVEDP | 6.6±0.2 | 7.7±1.5 | 7.3±1.4 | 7.8±0.9 | 6.8±0.7 | 6.0±0.9 | 4.5±0.9 | 3.8±1.1 |
| LVDP | 122±13 | 127±12 | 130±13 | 128±12 | 126±12 | 125±12 | 117±12 | 109±14 | |
| H R | 246±12 | 271±12 | 256±11 | 252±14 | 244±16 | 235±16 | 236±22 | 205±16 | |
| RPP | 30035±2069 | 34331±1954 | 32980±1420 | 31920±1371 | 30438±1510 | 29160±1745 | 27161±1727 | 21943±1273** | |
| CFR | 6.2±1.9 | 8.8±0.7 | 7.5±0.6 | 6.3±0.8 | 5.2±0.7 | 4.4±0.7 | 3.8±0.7 | 3.2±0.4* | |
| LC (5 mM) |
LVEDP | 6.2±1.3 | 13.5±1.5** | 13.8±1.0** | 10.4±0.4* | 9.6±1.5 | 9.0±1.6 | 7.0±1.5 | 4.2±1.2 |
| LVDP | 126±10 | 151±10 * | 156±10 * | 153±10 * | 149±10 | 144±9 | 137±10 | 133±11 | |
| H R | 221±23 | 276±11* | 236±26 | 254±12 | 252±8 | 251±7 | 241±11 | 233±12 | |
| RPP | 27894±3079 | 41489±2269*** | 36874±4168** | 38686±1883** | 37516±1411** | 36138±1298** | 33122±1463 | 33249±1721 | |
| CFR | 4.0±0.4 | 9.5±0.7*** | 7.4±0.6** | 6.4±0.6 | 5.7±0.6 | 5.0±0.6 | 4.5±0.7 | 4.1±0.8 | |
*** P<0.001, ** P<0.01, * P<0.05 versus pre-reperfusion value by using repeated ANOVA with LSD post test. n=6-8 in each group. LC; L-carnitine, LVEDP; left ventricular end diastolic pressure (mmHg), LVDP; left ventricular developed pressure (mmHg), HR; heart rate (beats/min), RPP; rate pressure product (mmHg.beats.min-1), CFR; coronary flow rate (ml/min), Pre-Rep; Pre-reperfusion time