Table 3.
Summary of published data showing skin thickness and hydroxyproline content in Tsk/+ and control mice.
| Strain background | Genotype | No. of mice studied | Age | Gender | Dermal thickness (mm) | Fold change in dermal thicknessb | Fold change in collagen or hydroxyproline contentb | Reference |
|---|---|---|---|---|---|---|---|---|
| B10.D2(58N)/Sn | Normal | 5 | 6 months | NGa | 1.1 ± 0.1 | Jimenez et al., 1984 [6] | ||
| B10.D2(58N)/Sn | Tsk | 5 | 6 months | NG | 2.2 ± 0.1 | 2.0 | 2.5 | |
|
| ||||||||
| NZB | pa/+ | 2 | NG | NG | Bocchieri et al., 1993 [19] | |||
| NZB | Tsk/+ | 2 | NG | NG | 2.3 | |||
|
| ||||||||
| C57BL/6 | pa/pa | 5 | 2-3 months | NG | ~0.180 | Ong et al., 1999 [15] | ||
| BALB/c, C57BL/6 | Tsk/+ IL4+/+, STAT6+/+ | 5 | 2-3 months | NG | ~0.380 | 2.1 | ||
| BALB/c, C57BL/6 | Tsk/+ IL4−/−, STAT6+/+ | 5 | 2-3 months | NG | ~0.190 | 1.0 | ||
| BALB/c, C57BL/6 | Tsk/+ IL4+/−, STAT6+/+ | 5 | 2-3 months | NG | ~0.290 | 1.6 | ||
| BALB/c, C57BL/6 | Tsk/+ IL4+/+, STAT6+/− | 5 | 2-3 months | NG | ~0.160 | 0.8 | ||
| BALB/c, C57BL/6 | Tsk/+ IL4+/+, STAT6−/− | 5 | 2-3 months | NG | ~0.170 | 0.9 | ||
|
| ||||||||
| C57BL/6 | pa/pa | 6 | NG | NG | 0.132 ± 0.042 | McGaha et al., 2001 [20] | ||
| C57BL/6 | Tsk/+ pa/+ | 13 | NG | NG | 0.228 ± 0.072 | 1.7 | 2.0 | |
| BALB/c, C57BL/6 | Tsk/+, Il4Rα+/− | 9 | NG | NG | 0.243 ± 0.088 | 1.8 | 1.5 | |
| BALB/c, C57BL/6 | Tsk/+, Il4Rα−/− | 9 | NG | NG | 0.135 ± 0.031 | 1.0 | 0.9 | |
| C57BL/6 | Tsk/+, Tgfb+/− | 16 | NG | NG | 0.164 ± 0.078 | 1.2 | 0.8 | |
| C57BL/6 | +/+, Tgfb+/− | 3 | NG | NG | 0.120 ± 0.018 | 0.9 | 0.8 | |
|
| ||||||||
| C57BL/6 | pa/pa | 6 | 3 months | NG | 0.118 ± 0.021 | Kodera et al., 2002 [16] | ||
| C57BL/6 | Tsk/+ pa/+ | 13 | 3 months | NG | 0.232 ± 0.089 | 1.9 | ||
| BALB/c, C57BL/6 | Tsk/+, Il4+/+ | 6 | 3 months | NG | 0.327 ± 0.081 | 2.7 | ||
| BALB/c, C57BL/6 | Tsk/+, Il4+/− | 12 | 3 months | NG | 0.205 ± 0.091 | 1.7 | ||
| BALB/c, C57BL/6 | Tsk/+, Il4−/− | 27 | 3 months | NG | 0.143 ± 0.042 | 1.2 | ||
| BALB/c, C57BL/6 | Tsk/Tsk, Il4+/− | 5 | 3 months | NG | 0.162 ± 0.023 | 1.4 | ||
| BALB/c, C57BL/6 | Tsk/Tsk, Il4−/− | 5 | 3 months | NG | 0.139 ± 0.019 | 1.2 | ||
|
| ||||||||
| C57BL/6 | +/+ | NG | 3 months | Female | ~0.160 | Saito et al., 2002 [21] | ||
| C57BL/6 | Tsk/+ | NG | 3 months | Female | ~0.390 | 1.1 | 1.25 | |
| C57BL/6, 129 | CD19 −/− | NG | 3 months | Female | ~0.160 | 1.0 | 1.0 | |
| C57BL/6, 129 | Tsk/+, CD19 −/− | NG | 3 months | Female | ~0.320 | 1.0 | 1.1 | |
|
| ||||||||
| C57BL/6 | +/+ | 11 | NG | 0.206 ± 0.021 | Del Prete et al., 2004 [22] | |||
| C57BL/6 | Tsk/+ | 8 | NG | 0.182 ± 0.089 | ||||
|
| ||||||||
| C57BL/6 | +/+ | 23 | 6 weeks | Male | ~0.8 | Baxter et al., 2005 [23] | ||
| C57BL/6 | Tsk/+ pa/+ | 34 | 6 weeks | Male | ~1.5 | 2.0 | ||
aNG: not given. bFold change is shown compared to control.