Table 1.
Composition and characterization of FLB core tablets
| Ingredients | Quantity (mg) | Core tablet evaluation parameters | n | Observed values |
|---|---|---|---|---|
| Flurbiprofen | 100 | Weight variation (mg) | 20 | 174.85 ± 2.92 |
| Spray dried lactose | 50.5 | Core thickness (mm) | 20 | 3.01 ± 0.02 |
| Crospovidone | 17.5 | Core diameter (mm) | 20 | 7.04 ± 0.01 |
| Sodium lauryl sulphate | 1.75 | Hardness (kg/cm2) | 6 | 2.83 ± 0.35 |
| Talc | 3.5 | Friability (%) | 10 | 0.58 |
| Magnesium stearate | 1.75 | Disintegration time (sec) | 3 | 35.67 ± 3.51 |
| Core weight | 175 | Content uniformity (%) | 3 | 100.28 ± 1.12 |
| % drug release in 15 min (Q 15) | 3 | 99.59 ± 0.69 |