Table 2.
Incidence of tumor of the IP6-treated rats with AOM-induced colon carcinogenesis.
| Group no. | Treatment | No. of rats | Incidence (%) of adenoma and/or adenocarcinoma | ||
|---|---|---|---|---|---|
| Adenoma | Adenocarcinoma | Total | |||
| 1 | Normal | 6 | 0 | 0 | 0 |
| 2 | AOM only | 6 | 4/6 (67%)a | 5/6 (83%)b | 5/6 (83%)b |
| 3 | AOM + 0.2% (w/v) IP6 | 6 | 3/6 (50%)c | 3/6 (50%)c | 4/6 (67%)d |
| 4 | AOM + 0.5% (w/v) IP6 | 6 | 1/6 (17%)e | 2/6 (33%)f | 3/6 (50%)g |
| 5 | AOM + 1% (w/v) IP6 | 6 | 1/6 (17%)e | 1/6 (17%)e | 2/6 (33%)f |
Groups: normal, AOM only, AOM + 0.2% (w/v) of IP6, AOM + 0.5% (w/v) of IP6, AOM + 1% (w/v) of IP6, and (IP6: inositol hexaphosphate, AOM: azoxymethane). Values in the same column with different superscript indicate significant difference by the Tukey's test (P < 0.05). Adenoma is defined as a benign tumor of glandular origin. Adenocarcinoma is a malignant tumor originating in glandular epithelium. Total tumor consists of both adenoma and adenocarcinoma in the colon tumor tissue.