Table 1.
Monocyte | Inflammatory macrophageintestinal macrophage | ||
---|---|---|---|
Phenotype | |||
CD4 | + | + | Low |
CD11a/LFA-1 | + | + | − |
CD11b/MAC-1 | + | + | − |
CD11c/integrin α | + | + | − |
CD13 | + | + | + |
CD14 | + | Low | − |
CD16/FcyRIII | + (subset) | + | − |
CD18/integrin β2 | + | + | − |
CD25/IL-2Rα | − | + | − |
CD32/FcyRII | + | + | − |
CD33 | + | − | + |
CD36 | + | + | + |
CD40/TNFRSF5 | + | + | − |
CD64/FcyRI | + | + | − |
CD69 | −(transient} | − | − |
CD80/B7-1 | − | + | − |
CD86/B7-2 | + | + | − |
CD88/C5aR | + | + | Low |
CD89/FcαR | + | + | − |
CD123/IL-3Rα | + | − | − |
CD181/CXCR1a | + | + | + |
CD182/CXCR2a | + | + | + |
CD184/CXCR4 | + | + | − |
CD195/CCR5 | + | + | − |
HLA-DR | + | + | + |
TGF-βRI | + | + | + |
TGF-βRII | + | + | + |
FPR1 | + | + | Low |
TREM-1 | + | + | − |
TLR1 | + | + | − |
TLR2 | + | + | − |
TLR4 | + | + | + |
TLR5 | + | + | + |
TLR6 | + | + | + |
TLR10 | + | + | ? |
TLR11 | + | + | ? |
Function | |||
Phagocytosis | + | + | + |
Killing | + | + | + |
Chemotaxis | + | +/− | − |
Respiratory burst | + | + | − |
Agpresentation | + | + | ? |
Cytokina production | + | + | − |
Costimulstion | + | + | − |
Abbreviations: C5aR, complement component 5a receptor; CCR5: C-C chemokine receptor type 5; CXCR, chemokine (C-X-C motif) receptor; FPR1, formyl peptide receptor 1; IL-2R; interleukin-2 receptor; LFA-1, lymphocyte function-associated antigen 1; MAC-1, macrophage-1 antigen; TGF-β, transforming growth factor-β; TLR, Toll-like receptor; TNFRSF5; tumor necrosis factor receptor superfamily, member 5; TREM-1, triggering receptor expression on myeloid cells 1; ?, not known.
CD181/CXCR1 = IL-8Rα: CD182/CXCR2 = IL-8Rβ