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. Author manuscript; available in PMC: 2013 Nov 10.
Published in final edited form as: Mucosal Immunol. 2010 Oct 20;4(1):10.1038/mi.2010.66. doi: 10.1038/mi.2010.66

Table 1.

Phenotypic and functional differences between monocytes, macrophages, and intestinal macrophages

graphic file with name nihms-511814-t0005.jpg

Monocyte Inflammatory macrophageintestinal macrophage
Phenotype
 CD4 + + Low
 CD11a/LFA-1 + +
 CD11b/MAC-1 + +
 CD11c/integrin α + +
 CD13 + + +
 CD14 + Low
 CD16/FcyRIII + (subset) +
 CD18/integrin β2 + +
 CD25/IL-2Rα +
 CD32/FcyRII + +
 CD33 + +
 CD36 + + +
 CD40/TNFRSF5 + +
 CD64/FcyRI + +
 CD69 −(transient}
 CD80/B7-1 +
 CD86/B7-2 + +
 CD88/C5aR + + Low
 CD89/FcαR + +
 CD123/IL-3Rα +
 CD181/CXCR1a + + +
 CD182/CXCR2a + + +
 CD184/CXCR4 + +
 CD195/CCR5 + +
 HLA-DR + + +
 TGF-βRI + + +
 TGF-βRII + + +
 FPR1 + + Low
 TREM-1 + +
 TLR1 + +
 TLR2 + +
 TLR4 + + +
 TLR5 + + +
 TLR6 + + +
 TLR10 + + ?
 TLR11 + + ?
Function
 Phagocytosis + + +
 Killing + + +
 Chemotaxis + +/−
 Respiratory burst + +
 Agpresentation + + ?
 Cytokina production + +
 Costimulstion + +

Abbreviations: C5aR, complement component 5a receptor; CCR5: C-C chemokine receptor type 5; CXCR, chemokine (C-X-C motif) receptor; FPR1, formyl peptide receptor 1; IL-2R; interleukin-2 receptor; LFA-1, lymphocyte function-associated antigen 1; MAC-1, macrophage-1 antigen; TGF-β, transforming growth factor-β; TLR, Toll-like receptor; TNFRSF5; tumor necrosis factor receptor superfamily, member 5; TREM-1, triggering receptor expression on myeloid cells 1; ?, not known.

a

CD181/CXCR1 = IL-8Rα: CD182/CXCR2 = IL-8Rβ