Table 3.
Significant gene expression changes in gene ontology categories determined using GSEA
| Description | Size | Test statistic |
|---|---|---|
| Up-regulated in evolved strains relative to parental | ||
| tricarboxylic acid cycle | 28 | −8.28 |
| aerobic respiration | 58 | −6.71 |
| regulation of transcription, DNA-dependent | 511 | −6.25 |
| mitochondrial electron transport, ubiquinol to cytochrome c | 11 | −5.45 |
| mitochondrial translation | 108 | −5.42 |
| transcription, DNA-dependent | 527 | −5.37 |
| electron transport chain | 48 | −5.12 |
| protein processing | 15 | −4.94 |
| signal transduction | 73 | −4.87 |
| response to stress | 150 | −4.68 |
| thiamin biosynthetic process | 17 | −4.61 |
| protein catabolic process | 17 | −4.43 |
| proteasomal ubiquitin-dependent protein catabolic process | 33 | −4.42 |
| mitochondrion organization | 36 | −4.31 |
| cellular carbohydrate metabolic process | 17 | −4.27 |
| Down-regulated in evolved strains relative to parental | ||
| arginine biosynthetic process | 10 | 5.01 |
| Gluconeogenesis | 18 | 5.09 |
| tRNA aminoacylation for protein translation | 35 | 5.10 |
| aromatic amino acid family biosynthetic process | 12 | 5.75 |
| maturation of SSU-rRNA from tricistronic rRNA transcript | 61 | 6.42 |
| cellular amino acid biosynthetic process | 98 | 7.02 |
| rRNA export from nucleus | 27 | 7.35 |
| Glycolysis | 25 | 7.67 |
| Translation | 241 | 10.33 |