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. 2013 Nov 11;3:74. doi: 10.3389/fcimb.2013.00074

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Copyright © 2013 Abbes, Mary, Sellami, Michel-Nguyen, Ayadi and Ranque.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Illustration of the effect of the complex interactions between CgPDH1, CgSNQ2, and CgERG11 drug resistance gene copy numbers and expression levels on fluconazole resistance in Candida glabrata clinical isolates. CgPDH1 gene copy number and expression were correlated, and their interaction led to an increase in fluconazole MIC levels. In contrast, the main effect of CgPDH1 overexpression independently led to a decrease in MIC levels. The main effect of CgSNQ2 overexpression independently promoted an increase in fluconazole MIC levels, while its interaction with CgERG11 expression led to a decrease in MIC levels.