Table 2.

Relative gene expression levels and copy numbers of CgCDR1, CgPDH1, CgERG11, and CgSNQ2 in fluconazole sensitive and resistant Candida glabrata isolates.

Patients	Isolates	Sample site	Microsatellite type	Fluconazole MIC (μg/ml)	Relative increase in
					CDR1 expression	CDR1 copies	PDH1 expression	PDH1 copies	ERG11 expression	ERG11 copies	SNQ2 expression	SNQ2 copies
1	1.1	Urine	3	1.5	3.09	4.59	6.62	1.99	0.4	0.74	1.11	0.18
1	1.2	Urine	3	256	5.64	4.7	20.04	4.13	0.54	1549.94	0.48	364.12
2	2.1	Urine	5	16	ND	2.01	ND	1.85	ND	1.55	ND	2.13
2	2.2	Urine	5	256	92.61	1.83	169.56	1.37	0.12	1.6	5.41	0.94
3	3.1	Vaginal	9	2	0.12	2.16	0.44	1.61	0.24	2.3	0.07	1.58
3	3.2	Vaginal	9	256	0.29	2.18	0.57	1.27	1.16	1.41	0.19	1.65
4	4.1	Urine	1	4	ND	1.48	0.11	1.14	0.53	3.35	0.04	0.99
4	4.2	Urine	1	256	0.1	2.32	9.42	0.83	0.3	3.14	1.19	1.44
5	5	Urine	1	256	1.84	1.11	7.64	1.16	0.56	0.91	0.97	1.22
6	6.1	Urine	8	32	0.1	1.02	0.49	0.9	0.94	0.93	0.56	0.82
6	6.2	Urine	2	256	2.54	4.04	375.57	5.7	4.34	12.7	73.61	0.56
7	7	Blood culture	7	256	0.39	1.89	5.6	2.71	0.42	2.01	5.77	1.2
8	8	Urine	9	256	12.06	3.64	0.31	3.21	0.23	3.74	1.17	3.24
9	9	Blood culture	7	256	12.14	1.27	0.59	0.89	0.87	1.01	2.17	1.03
10	10	Blood culture	7	32	1.42	1.25	0.27	1.01	0.25	1.84	0.26	1.56
11	11.1	Urine	12	1	0.34	ND	15.08	ND	1.11	ND	12.93	ND
11	11.2	Urine	4	32	0.46	1.21	4.86	1.38	0.57	0.79	0.45	1.04
11	11.3	Urine	10	32	0.65	1.25	0.87	0.86	0.54	1.84	1.72	ND
12	12	Blood culture	10	1	0.43	1.41	0.46	2.05	0.09	1.45	0.01	1.28
13	13	Blood culture	6	2	ND	1.73	0.04	1.21	0.27	1.29	0.22	0.85
14	14	Blood culture	10	2	0.3	1.68	0.26	1.17	0.16	1.68	0.37	1.39
15	15	Kidney abscess	13	3	ND	1.59	0.76	1.93	0.42	1.6	0.99	0.7
16	16	Lung abscess	14	2	0.23	1.24	0.35	0.79	0.31	1.07	0.47	0.95
17	17	Urine	14	2	0.18	1.75	0.46	1.52	0.26	3.86	0.42	0.77
18	18	Blood culture	15	2	0.09	1.74	0.25	0	0.26	2.1	0.3	1.12
19	19.1	Urine	7	0.064	0.019	1.26	0.94	1.32	1.23	1.19	0.49	1.31
19	19.2	Urine	7	0.125	0.04	1.2	0.79	1.14	0.38	0.99	0.52	0.69
20	20	Blood culture	7	4	1.3	1.47	17.05	1.67	1.78	1.32	0.48	1.83
21	21.1	Urine	4	6	6.71	1.16	3.59	1.25	2.34	4.03	3.56	0.41
21	21.2	Urine	4	4	0.86	2.76	0.74	2.57	0.71	2.57	0.69	2.82
21	21.3	Urine	4	4	0.82	1.4	0.96	1.51	1.32	1.38	0.79	1.67
21	21.4	Urine	4	8	0.01	2.16	0.57	1.61	1.89	2.3	1.72	1.75
21	21.5	Urine	4	4	2.63	2.31	2.9	1.96	1.05	1.76	2.14	1.6
22	22	Blood culture	3	4	1.59	1.71	1.13	1.75	0.74	1.34	1.18	1.43
23	23	Urine	4	4	1.81	1.62	2.79	1.48	0.52	1.46	1.79	1.61
24	24	Urine	16	4	0.12	1.71	0.29	1.18	0.43	1.1	0.25	1.28
25	25	Urine	10	0.5	0.03	ND	1.61	2.61	0.09	1.36	0.1	48.88
26	26.1	Urine	9	0.016	ND	4.19	2.76	2.23	1	1.15	0.35	0.37
26	26.2	Urine	9	6	0.4	ND	0.88	ND	0.84	ND	0.59	ND
27	27	Blood culture	11	8	ND	ND	0.76	ND	0.7	ND	0.15	ND
28	28	Blood culture	3	1	0.2	4.27	1.16	2.41	2.09	1.59	0.34	0.66
29	29	Blood culture	9	4	ND	1.73	1.26	0.64	0	0.55	0.69	0.77
30	30	Blood culture	17	2	0.01	1.18	1.04	1.09	0.98	0.78	2.08	0.75