Hsp70 OVEREXPRESSION |
Hsp70 transgenic mice |
10–12 months adult mice |
Decreased body and muscle mass |
McArdle et al., 2004
|
|
Aging |
Preservation of muscle specific force |
McArdle et al., 2004
|
|
Muscle damage/eccentric contractions |
Decreased muscle damage, improved muscle functional recovery (adult and old mice) |
McArdle et al., 2004
|
|
Muscle damage/cryolesioning |
Decreased muscle damage, improved morphological recovery |
Miyabara et al., 2006
|
|
Modified muscle use/cast- immobilization and recovery |
Improved muscle structural and functional recovery |
Miyabara et al., 2012
|
|
Muscular dystrophy/crossed with mdx mice |
Improved muscle morphology and function |
Gehrig et al., 2012
|
Hsp70 plasmid electroporation |
Muscle atrophy/cast-immobilization |
Attenuation of disuse muscle fiber atrophy (adult and old rats) |
Senf et al., 2008; Dodd et al., 2009
|
|
Muscle damage/freeze injury |
Increased CSA of regenerating muscle fibers |
Moresi et al., 2009
|
Hsp70 KNOCKDOWN |
Hsp70 knockout mice |
12–15 weeks adult mice |
Decreased muscle fiber CSA, decreased muscle specific force |
Senf et al., 2013
|
|
Muscle damage/direct cardiotoxin injection |
Delayed inflammatory response to injury, impaired muscle regeneration and recovery (smaller CSA of regenerating fibers, sustained inflammation, fibrosis and calcium deposition) |
Senf et al., 2013
|
|
Modified muscle use/cast-immobilization and recovery |
Decreased muscle reloading damage, decreased size of regenerating fibers |
Senf et al., 2013
|