Figure 2.

Intrarenal localization or expression of major components of the renin-angiotensin system. (A) Active renin binding in juxtaglomerular apparatus in the dog kidney using the radiolabeled renin inhibitor, ¹²⁵I-H77. (B) ACE binding in the proximal tubule of the rat kidney using ¹²⁵I-351A (C) AT₁ receptor binding in the rat kidney in the presence of the AT₂ receptor blocker PD123319. (D) AT₂ receptor binding in the rat kidney in the presence of the AT₁ receptor blocker losartan using ¹²⁵I-[Sar¹,Ile⁸]-Ang II. (E) Ang (1–7) receptor binding in the rat kidney using ¹²⁵I-Ang (1–7) as the radioligand. And (F) Ang IV receptor binding in the rat kidney using ¹²⁵I-Ang (3–8). The levels of binding are indicated by color calibration bars with red representing the highest, whereas blue showing the lowest levels of enzyme or receptor binding. G, glomerulus; IM, inner medulla; IS, inner stripe of the outer medulla; JGA, juxtaglomerular apparatus; P, proximal tubule. Reproduced from Li and Zhuo with permission (45).