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Inhibition of CXCR4-mediated chemotaxis by S1PR1 signalling. Primary resting human T cells were incubated overnight in serum-free medium. The cells were pre-treated for 1 hr with vehicle, 10 nM, 1 μM or 10 μM of the selective S1PR1 agonist SEW2871, then 100,000 cells left to migrate towards 6.25 nM CXCL12 for 2 hrs.
