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. Author manuscript; available in PMC: 2013 Nov 11.
Published in final edited form as: Bipolar Disord. 2011 May;13(3):10.1111/j.1399-5618.2011.00920.x. doi: 10.1111/j.1399-5618.2011.00920.x

Fig. 4.

Fig. 4

(A) SPM(t) maps showing nonsuppression of the left orbitofrontal cortex (OFC) (BA 47) during working memory (WM) in first-degree relatives of persons with bipolar disorder (RELS) compared to controls (CON) after controlling for IQ scores, replicating (B) our previous work showing exaggerated signal in the same region in older adult RELS compared to CON (13). [2-back WM > 0-back task contrast; MNI coordinates of peak voxel: (A): x = −15, y = 27, z = −15; (B): x = −24, y = 12, z = −18]. Graph depicts parameter estimates [mean blood-oxygen-dependent (BOLD) fMRI signal change, with standard error bars] extracted from the OFC cluster for the 0-back (0B) and 2-back (2B) conditions relative to fixation (represented by the zero baseline) for each group.