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. 2013 Feb 27;17(4):482–496. doi: 10.1111/jcmm.12028

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Copyright © 2013 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd.

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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Fig. 9 — Diffuse cutaneous systemic sclerosis (dcSSc) skin, transmission electron microscopy. (A) Early dcSSc. An activated fibroblast displays a particularly extended cytoplasm containing an abundant rough endoplasmic reticulum and a large Golgi apparatus (asterisk). (B and C) Advanced dcSSc. Some fibroblasts embedded in the fibrotic extracellular matrix show ultrastructural features suggestive of a functional exhaustion, such as extremely dilated endoplasmic reticulum cisternae (B) or a clear and empty cytoplasm (C). Note a mast cell in close contact with the fibroblast (C). (D) Advanced dcSSc. Myofibroblasts show a large body with short and thick processes and are rich in cisternae of rough endoplasmic reticulum, mitochondria and myofilaments. Subplasmalemmal focal densities are evident (arrowheads). F: fibroblast; MC: mast cell; My: myofibroblast. Scale bars are indicated in each panel.