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. 2013 Mar 11;17(4):508–517. doi: 10.1111/jcmm.12034

Fig. 3.

Fig. 3

MAPK inhibition affects chondrocyte density and matrix deposition in monolayer culture. Top panels: Phase images of chondrocytes on day 7 after 48 hrs of treatment with specific MAPK inhibitors. Scale bar: 200 μm. Middle panels: Whole-plate Safranin O staining indicating deposited GAG on day 7. Scale bar: 500 μm. Bottom panels: Immunofluorescence microscopy staining for collagen type II deposits on the culture surface on day 7. Arrows indicate more organized networks of collagen type II. Blue: DAPI for nuclei, red: collagen type II. Scale bar: 200 μm.