Table 3.
Proteins down-regulated in Alzheimer's disease
| Accession number | Registered record in SWISSPROT | Protein description | Mean ratio (AD/control) |
|---|---|---|---|
| P04075 | ALDOA_HUMAN | Fructose-bisphosphate aldolase A | 0.22 |
| P80723 | BASP_HUMAN | Brain acid soluble protein 1 | 0.21 |
| Q2PPJ7 | AS250_HUMAN | 250 kD substrate of Akt | 0.21 |
| Q96FN5 | KIF12_HUMAN | Kinesin-like protein KIF12 | 0.21 |
| P62258 | 1433E_HUMAN | 14-3-3 protein epsilon | 0.21 |
| A6NDB9 | PALM3_HUMAN | Paralemmin-3 | 0.20 |
| Q9P273 | TEN3_HUMAN | Teneurin-3 | 0.20 |
| Q13153 | PAK1_HUMAN | Serine/threonine-protein kinase PAK 1 | 0.18 |
| A6NN79 | PERPL_HUMAN | Putative PERP-like protein | 0.17 |
| Q15262 | PTPRK_HUMAN | Receptor-type tyrosine-protein phosphatase kappa | 0.16 |
| Q2KJY2 | KI26B_HUMAN | Kinesin-like protein KIF26B | 0.16 |
| P27348 | 1433T_HUMAN | 14-3-3 protein theta | 0.16 |
| P51991 | ROA3_HUMAN | Heterogeneous nuclear ribonucleoprotein A3 | 0.16 |
| P09972 | ALDOC_HUMAN | Fructose-bisphosphate aldolase C | 0.16 |
| Q6UXK2 | ISLR2_HUMAN | Immunoglobulin superfamily containing leucine-rich repeat protein 2 | 0.15 |
| Q8TEW8 | PAR3L_HUMAN | Partitioning defective 3 homologue B | 0.14 |
| Q5QHF1 | CT199_HUMAN | Uncharacterized protein C20orf199 | 0.13 |
| P07101 | TY3H_HUMAN | Tyrosine 3-monooxygenase | 0.12 |
| Q6W2J9 | BCOR_HUMAN | BCL-6 co-repressor | 0.11 |
| Q5T215 | TPC3L_HUMAN | Trafficking protein particle complex subunit 3-like protein | 0.10 |
| Q9BXS6 | NUSAP_HUMAN | Nucleolar and spindle-associated protein 1 | 0.10 |
| Q15615 | OR4D1_HUMAN | Olfactory receptor 4D1 | 0.10 |
| Q92614 | MY18A_HUMAN | Myosin-XVIIIa | 0.10 |
| P52735 | VAV2_HUMAN | Guanine nucleotide exchange factor VAV2 | 0.09 |
| P62158 | CALM_HUMAN | Calmodulin | 0.09 |
| Q8TAG9 | EXOC6_HUMAN | Exocyst complex component 6 | 0.09 |
| O15226 | NKRF_HUMAN | NF-kappa-B-repressing factor | 0.09 |
| P25713 | MT3_HUMAN | Metallothionein-3 | 0.09 |
| P10809 | CH60_HUMAN | 60 kDa heat shock protein, mitochondrial | 0.08 |
| Q13023 | AKAP6_HUMAN | A-kinase anchor protein 6 | 0.08 |
| O75586 | MED6_HUMAN | Mediator of RNA polymerase II transcription subunit 6 | 0.07 |
| Q96PX9 | PKH4B_HUMAN | Pleckstrin homology domain-containing family G member 4B | 0.06 |
| P02452 | CO1A1_HUMAN | Collagen alpha-1(I) chain | 0.04 |
| Q13451 | FKBP5_HUMAN | FK506-binding protein 5 | 0.02 |
| P02461 | CO3A1_HUMAN | Collagen alpha-1(III) chain | 0.02 |
| P16152 | CBR1_HUMAN | Carbonyl reductase ADPH] 1 | 0.02 |
| Q9HCH0 | K1602_HUMAN | Uncharacterized protein KIAA1602 | 0.02 |
| Q6ZU80 | CN145_HUMAN | Uncharacterized protein C14orf145 | 0.00 |