Table 1.
Physiological parameters
| 7-min. ischaemia Control, n= 34(3*) | EPO, n= 32(3*) | P value | 9-min. ischaemia Control, n= 30(3*) | EPO, n= 35(3*) | P value | |
|---|---|---|---|---|---|---|
| HR (beats/min.) | ||||||
| Pre-ischaemia | 265 ± 68 | 286 ± 60 | 0.187 | 265 ± 36 | 270 ± 50 | 0.685 |
| Reperfusion | 269 ± 67 | 315 ± 50 | 0.003† | 266 ± 45 | 298 ± 48 | 0.008† |
| MAABP (mmHg) | ||||||
| Pre-ischaemia | 61.2 ± 18.2 | 62.8 ± 12.9 | 0.671 | 68.1 ± 12.2 | 68.6 ± 14.5 | 0.881 |
| Ischaemia | 11.6 ± 2.0 | 12.0 ± 2.8 | 0.545 | 11.3 ± 4.6 | 10.7 ± 3.7 | 0.622 |
| Reperfusion | 53.5 ± 9.9 | 57.5 ± 10.8 | 0.125 | 59.0 ± 11.6 | 62.3 ± 8.1 | 0.199 |
| RT (°C) | ||||||
| Pre-ischaemia | 36.5 ± 0.7 | 36.5 ± 0.4 | 0.679 | 36.4 ± 0.4 | 36.4 ± 0.4 | 0.962 |
| Ischaemia | 35.8 ± 0.5 | 36.0 ± 0.3 | 0.224 | 35.8 ± 0.3 | 35.8 ± 0.3 | 0.821 |
| Reperfusion | 36.6 ± 0.5 | 36.5 ± 0.4 | 0.325 | 36.6 ± 0.4 | 36.6 ± 0.5 | 0.657 |
| BGA parameters | ||||||
| pH | ||||||
| Pre-ischaemia | 7.36 ± 0.02 | 7.38 ± 0.04 | 0.496 | 7.38 ± 0.05 | 7.35 ± 0.07 | 0.578 |
| Reperfusion | 7.28 ± 0.00 | 7.30 ± 0.03 | 0.368 | 7.22 ± 0.01 | 7.25 ± 0.06 | 0.480 |
| PaO2 (mmHg) | ||||||
| Pre-ischaemia | 76.5 ± 0.1 | 75.4 ± 4.5 | 0.713 | 78.2 ± 3.8 | 80.1 ± 4.2 | 0.592 |
| Reperfusion | 71.0 ± 0.2 | 74.6 ± 3.7 | 0.234 | 79.6 ± 5.2 | 77.7 ± 0.2 | 0.592 |
| PaCO2 (mmHg) | ||||||
| Pre-ischaemia | 44.6 ± 2.1 | 40.3 ± 3.3 | 0.130 | 40.8 ± 3.8 | 40.4 ± 4.3 | 0.910 |
| Reperfusion | 38.1 ± 2.1 | 34.6 ± 2.1 | 0.111 | 36.2 ± 0.4 | 36.5 ± 3.0 | 0.879 |
| BE | ||||||
| Pre-ischaemia | −0.8 ± 0.2 | −0.8 ± 0.9 | 0.935 | −0.2 ± 1.0 | −0.9 ± 1.2 | 0.481 |
| Reperfusion | −9.2 ± 0.7 | −10.0 ± 0.5 | 0.183 | −11.9 ± 1.6 | −11.7 ± 1.8 | 0.893 |
| HCT (%) | ||||||
| Pre-ischaemia | 45.3 ± 1.5 | 43.5 ± 0.7 | 0.164 | 42.7 ± 2.3 | 47.0 ± 1.7 | 0.060 |
| Reperfusion | 46.0 ± 3.5 | 45.5 ± 0.7 | 0.830 | 45.5 ± 4.9 | 48.0 ± 1.4 | 0.476 |
Values are given as mean±S.D. EPO: erythropoietin; HR: heart rate; MAABP: mean abdominal aortic blood pressure; RT: rectal temperature; BE: base excess; HCT: haematocrit; pre-ischaemia, 10 min. before ischaemia; ischaemia, at the end of ischaemia; reperfusion, 10 min. after the onset of reperfusion. *Numbers for BGA analysis. †Significant values.