Fig 1.
Neurological disability score for EAE animals induced to a state of MS. Disability scores range from a mean clinical disability score of 0 (no disability) to 15 (maximum disability). The bell shaped distribution outlining peak neurological disability in response to EAE induction occurred at day 12 post-EAE induction. Neurological disability is scored according to the following criteria: Tail: 0 = normal; 1 = partially paralysed, weakness; 2 = completely paralysed, limp. Bladder: 0 = normal; 1 = incontinence. Right hind limb: 0 = normal; 1 = weakness; 2 = dragging with partial paralysis; 3 = complete paralysis. Left hind limb: 0 = normal; 1 = weakness; 2 = dragging with partial paralysis; 3 = complete paralysis. Right forelimb: 0 = normal; 1 = weakness; 2 = dragging, not able to support weight; 3 = complete paralysis. Left forelimb: 0 = normal; 1 = weakness; 2 = dragging, not able to support weight; 3 = complete paralysis.