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. 2012 Jul 29;16(8):1900–1915. doi: 10.1111/j.1582-4934.2011.01485.x

Fig 4.

Fig 4

Local stem cell transplantation reverses visceral hypersensitivity and restores intestinal permeability. (A) Colonic distension pressures that elicited the nociceptive threshold for each IL-10−/− mice. Bar graph of colon distension pressures in mmHg versus time course in IL-10−/− mice following stem cell treated or colonic epithelium cell treatment. Error bars are expressed as means ± S.D. There was significantly decreased visceral hypersensitivity at 14, 21 and 28 days (*P < 0.05; **P < 0.01) following CSCs treatment compared to baseline and CECs treated IL-10−/−mice (A, lower panel). Upper plane of (A) shows EMG measurement at 14 days following CSCs infusion compared to CECs treated mouse with 35 mmHg distension pressure. There is a reduced EMG activity that demonstrated at IL-10−/− mouse its received CSCs treatment. (B, left side) IL-10−/− mice with active colitis exhibit increased intestinal permeability (decreased resistance of the intestinal barrier). Increased intestinal permeability (decreased resistance) was negatively correlated with increases in the colitis-related pathology scores (r=–0.75; P < 0.001). An analysis of in vitro intestinal permeability is shown in the right side of (B). IL-10−/− mice without any treatment and CECs treated IL-10−/− mice had increased intestinal permeability (decreased resistance) compared to normal control (wild-type) mice and CSC-treated mice (P < 0.01). No significant changes were detected in permeability between CECs treated IL-10−/− mice and untreated IL-10−/− mice.