Fig 6.

Identification of signal transduction pathway involved when TFPI-2 is down-regulated in lung cancer cells. Using a luciferase pathway reporter array, the firefly luciferase activity of inducible transcription factor-responsive construct transfected in miRNA clones was measured and related to Renilla luciferase activity of constitutively expressing Renilla luciferase construct measured in the same cells for normalizing transfection efficiencies. Results represent the mean ± S.E.M. of experiments performed with miRNA-Neg clone, miRNA-1b and miRNA-2b clone (n= 7). (*P < 0.05, compared with the miRNA-Neg clone, Student t-test).