Fig 3.

SPTT restrains proliferation and induces apoptosis of prostate cancer cells in vitro. (A) The results of BrdUrd assay showed that significant anti-proliferative effects were induced by SPTT in both PC3 and LNCaP cell lines, whereas the super-natants of normal MSCs and mock-transduced MSCs did not affect the proliferation of either cell line. (B) SPTT induced apoptosis of prostate cancer cells. Annexin V-FITC/PI staining demonstrated that the apoptosis rate of prostate cancer cells increased after treatment with conditioned media from SPTT-MSCs (*P< 0.05 compared to mock-transduced MSCs).