Fig 4.

SPTT-MSCs directly inhibit the growth of PC3 cells in vitro, and decrease angiogenesis. (A) SPTT-MSCs and PC3 cells were mixed in vitro at a 1:5 ratio in a co-culture system for 72 hrs. The survival of PC3 cells was significantly decreased by co-culture with the SPTT-MSCs (*P< 0.05 compared to mock-transduced MSCs), whereas co-culture with EGFP-MSCs did not have any significant effect on their survival. (B) Compared with media from control MSCs (I) and EGFP-MSCs (II), the conditioned media from SPTT-MSCs (III), significantly inhibited endothe-lial tube formation. (C) The extent of tube formation after treatment with conditioned media from SPTT-MSCs was less than half of that observed in the control MSCs- and EGFP-MSCs-treated groups.