Table 1.
Distribution of 72 MBC cases according to SULT1A1 gene deletion and clinical-pathologic features
| SULT1A1 | |||
|---|---|---|---|
| Parameter* | Deletion (%) | No deletion (%) | P value† |
| Family history of breast/ovarian cancer | |||
| Negative | 4 (8.2) | 45 (91.8) | 0.06 |
| Positive | 6 (27.3) | 16 (72.7) | |
| Personal history of cancer | |||
| Negative | 7 (11.7) | 53 (88.3) | 0.18 |
| Positive | 3 (27.3) | 8 (72.7) | |
| BRCA1 status | |||
| BRCA1 wt | 10 (14.5) | 59 (85.5) | |
| BRCA1 mutation | 0 (0) | 2 (100.0) | 1.0 |
| BRCA2 status | |||
| BRCA2 wt | 4 (6.3) | 60 (93.7) | <0.0001 |
| BRCA2 mutation | 6 (85.7) | 1 (14.3) | |
| ER | |||
| Negative | 4 (40) | 6 (60.0) | 0.033 |
| Positive | 6 (9.7) | 56 (90.3) | |
| PR | |||
| Negative | 4 (25.0) | 12 (75.0) | 0.12 |
| Positive | 6 (10.7) | 50 (89.3) | |
| HER2 | |||
| Negative | 5 (9.4) | 48 (90.6) | 0.12 |
| Positive | 4 (22.2) | 14 (77.8) | |
| Ki-67 | |||
| Low | 4 (10.0) | 36 (90.0) | 0.2 |
| High | 5 (16.1) | 26 (83.9) | |
| Histological grade | |||
| G1/G2 | 3 (6.8) | 41 (93.2) | 0.06 |
| G3 | 6 (25.0) | 18 (75.0) | |
| Lymph node status | |||
| Negative | 1 (3.9) | 25 (96.2) | 0.35 |
| Positive | 4 (14.3) | 24 (85.7) | |
| Total | 10 (13.9) | 62 (86.1) | |
*
Some data for each parameter are not available.
†
From Fisher exact test.
‡
This association was not evident in a multivariate analysis.