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. 2013 Apr 20;17(5):648–656. doi: 10.1111/jcmm.12046

Fig. 3.

Fig. 3

Combinations of PI3K/AKT inhibitors and EGFR inhibitors exert synergistic cytotoxicity in the susceptible cells. (A) SUM149PT cells were treated with various combinations of PI3K/AKT inhibitors and EGFR inhibitors for ∼72 hrs. (B) MDA-MB-468 cells were treated with gefitinib in combination with either PI-103 or MK-2206 for ∼72 hrs. (C) The non-susceptible cells (HS578T, MDA-MB-231, MDA-MB-436) were treated with gefitinib in combination with either PI-103 or MK-2206 for ∼72 hrs. (A–C) Viable cells were measured by MTT assay as described in Materials and methods. Data from two independent experiments performed in triplicate are shown as mean ± SEM. Abbreviations: Erlo, erlotinib; Gef, gefitinib; PI, PI-103; MK, MK-2206. *P < 0.05; **P < 0.01; ***P < 0.001.