Fig 2.
Effect of chronic stress on murine melanoma cancer growth. In vivo tumour growth of B16F10 cells was measured in C57BL/6 mice. The animals were distributed into three groups (10 animals/group). Two groups of animals received a pre-treatment with placebo (PBS) or with propranolol for seven days and then exposed to a physical restraint. After seven days, the animals were injected subcutaneously with 3 χ 105 cells/mouse in the right hind footpad B16F10 cells. Differences in growth were analysed by ANOVA (n= 10; P < 0.0001). Mean tumour volume ± S.E.M. are given.