1.

Nuclear regulation of NF-κB. A number of proteins have been reported to regulate NF-κB activity in the nucleus. Some of these, such as Bcl-3 and UXT, bind directly to the members of the NF-κB complex, while other proteins catalyse post-translational modifications of NF-κB subunits. Bcl-3, B cell lymphoma-3; UXT, ubiquitously expressed transcript; HATs, histone acetyl transferases; HDACs, histone deacetylases.

Name of the regulator	Mechanism of action
Bcl-3	Binds to p50 and p65 subunits
IκB ζ	Binds to p50 and p65 subunits
UXT	Binds to p65 subunit
ZAS3	Competes for IκB regulatory elements
HATs	Acetylates histones and transcription factors
HDACs	Deacetylates histones and transcription factors
Kinases	Phosphorylates NF-κB subunits