Table 1.
Gender bias of T1D in NOD colonies.
| Institution | Female (F) | Male (M) | Ratio F/M |
|---|---|---|---|
|
SPF Facilities
| |||
| U of Chicago | 60% | 25% | 2.4 |
| Yale 2008 (Wen et al., 2008) | 90% | 70% | 1.3 |
| Taconic 2009* | 80% | 50% | 1.6 |
| Harvard 2011 (Kriegel et al., 2011) | 50–60% | 10–15% | 4.4 |
| 2002** | 75% | 50% | 1.5 |
| 2003** | 85% | 60% | 1.4 |
| 2004** | 90% | 45% | 2.0 |
| 2005** | 80% | 40% | 2.0 |
| 2006** | 65% | 35% | 1.9 |
| 2007** | 100% | 65% | 1.5 |
| 2008** | 90% | 85% | 1.1 |
| 2009** | 90% | 65% | 1.4 |
|
| |||
|
Germ-Free Facilities
| |||
| Taconic 2008 (Wen et al., 2008) | 100% | 85% | 1.2 |
| U of Chicago 2012 | 95% | 84% | 1.1 |
Cumulative incidence of diabetes in NOD mice at 30 weeks of age.
*
Taconic Farms NOD incidence study. http://www.taconic.com/user-assets/Documents/Products%20and%20Services/Animal%20Models/NOD_Onset_2009.pdf
**
T1DR-T1D repository at The Jackson Laboratory. Data available at http://type1diabetes.jax.org/gqc_incidence_studies.html