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. Author manuscript; available in PMC: 2013 Nov 11.
Published in final edited form as: Clin Pharmacol Ther. 2011 May 4;89(6):867–874. doi: 10.1038/clpt.2011.47

Table 2.

P values for the regression of Principal Component 1a against various demographic variables, using both the entire data set and the data set broken out into the three groups (CBZ, VPA and control). Significant correlations are noted by bold type.

Variable All CBZ Control VPA
Group <0.0001 - - -
Age <0.0001 <0.0001 0.0005 <0.0001
Gender 0.7373 0.9514 0.5308 0.8603
Race 0.6576 0.9027 0.5130 0.1453
Weight <0.0001 0.0003 0.0002 <0.0001
Dose <0.0001 0.1121 - 0.0019
Concurrent Medications - - - 0.5339
a

Principal Component 1 represents the linear combination of factors that accounts for the largest amount of variability in the data, and each succeeding component (PC2, PC3) has the highest variance possible under the constraint that it is uncorrelated with the preceding components. PC1 accounted for 31.2% of the variability in the current dataset.