Effect of initial size of treated tumors on the tumor growth response for the treatments with 5 mg/kg of DOX. The arrows indicate the schedule for treatments. (A) and (B) are the tumor growth responses for an initial size of treated tumors ≤30 mm3 and ≥100 mm3, respectively. N = 5 for each group, mean ± SD, and *P <0.05 (Mann-Whitney U test). Reprinted from Nanomedicine: Nanotechnology Biology and Medicine, Lin C-Y, Li J-R, Tseng H-C, Wu M-F, Lin W-L , “Enhancement of focused ultrasound with microbubbles on the treatments of anticancer nanodrug in mouse tumors”, 1-8, (2011), with permission from Elsevier.