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. 2011 Oct 24;15(11):2353–2363. doi: 10.1111/j.1582-4934.2010.01222.x

Fig 3.

Fig 3

Menin represses tumour growth and metastasis of melanoma cells in vivo. (A) The efficiency of menin overexpression was determined by Western blotting. (B) Menin overexpressing B16 cells were injected subcutaneously into nude mice and tumour formation was examined day 14 after transplantation. N= 8, *P < 0.05. (C) The efficiency of PTN silencing was determined by Western blotting. (D) The PTN-shRNA expression B16 cells were injected subcutaneously into nude mice, and tumour formation was examined day 14 after transplantation, N= 8, *P < 0.05. (E and F) The number of macroscopic pulmonary metastases from each mouse treated with menin overexpressing B16 cells, N= 5. (G and H) The number of macroscopic pulmonary metastases from each mouse treated with PTN-shRNA B16 cells, N= 6 or 7.