Fig 1.

MiR-24 is down-regulated in different areas of the heart after MI. (A) miRNAs were isolated in different areas of the infracted heart and sham-opened hearts 1, 2, and 4 weeks after MI. qRT-PCR was done to determine levels of miR-24 in MI areas and in control groups. Compared with sham-operated hearts, miR-24 expression was significantly decreased in MI areas. (B–D) qRT-PCR was done to determine expression of collagen-1 (B), fibronectin (C), and TGF-β1 (D) in the same samples as (A) (I: infarct zone; BZ: border zone; R: remote zone; n = 3 for each time-point; mean ± S.E.M. *P < 0.05, **P < 0.01 compared with sham groups).