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. 2012 Aug 23;16(9):2150–2160. doi: 10.1111/j.1582-4934.2012.01523.x

Fig 6.

Fig 6

Target of miR-24 and proposed model of miR-24 function. (A) Expression of furin protein was detected by western blotting and normalization to GAPDH. (B) qRT-PCR revealed furin mRNA expression in CFs transfected with a pre-miR-24 mimic or anti-miR-24 inhibitor. Mean ± S.E.M., *P < 0.05, **P < 0.01 (n = 3). (C) Furin putative miR-24 binding sites (potential complementary residues shown in red). (D) CFs were transfected with siRNA of furin, and expression of furin, Collagen-1 and α-SMA was determined by western blotting and quantitative determination (n = 3). (E) qRT-PCR analysis for Furin, Collagen-1 and α-SMA mRNA expression. Mean ± S.E.M. *P < 0.05. **P < 0.01 compared with control siRNA group (n = 4). (F) Proposed model for the regulation of miR-24 in fibrosis after myocardial infarction.