Fig 1.

Effects of K5-N,OSepi on myocardial infarct size evoked by regional I/R. (A) Dose–response effects of K5-N,OSepi (0.1–1 mg/kg) on the extension of left ventricular myocardium with I/R-induced injury, as evaluated on hearts stained with nitro-blue tetrazolium and (B) quantification of infarct size after I/R injury, expressed as per cent of area at risk (AAR), in the absence (vehicle) or presence of K5-N,OSepi (0.3–1 mg/kg) or B4/100 (1 mg/kg). Data are means ± SEM of six animals/group. *P < 0.01 versus vehicle (1 hr reperfusion) and •P < 0.01 versus vehicle (24 hrs reperfusion).