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Dose–response effects of K5-N,OSepi on lipid peroxidation, free-radical-induced DNA damage and calcium release in left ventricular tissue. TBARS production (A), 8-OHdG levels (B) and calcium content (C) were measured subsequent to sham operation (Sham) or I/R (30/60 min.) in the absence (vehicle) or presence of K5-N,OSepi (0.1–1 mg/kg) or B4/100 (1 mg/kg) treatment. Data are means ± S.E.M. of eight animals/group. *P < 0.01 versus vehicle.
