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Test characteristics of cycle sequencing and real-time PCR-based assay for KRAS mutation assessment (n 5 510)
| Cycle sequencing | Real-time PCR-based assay | |
|---|---|---|
| Sensitivity | 95.5% | 96.5% |
| (95% CI) | (91.7–97.9%) | (93.0–98.6%) |
| Specificity | 99.7% | 98.1% |
| (95% CI) | (98.2–100%) | (95.8–99.3%) |
| Positive predictive value | 99.5% | 97.0% |
| (95% CI) | (97.1–100%) | (93.6–98.9%) |
| Negative predictive value | 97.2% | 97.7% |
| (95% CI) | (94.7–98.7%) | (95.4–99.1%) |
