Fig 1.

Scriptaid induces apoptosis in glioma cells. (A) Scriptaid decreases viability of glioma cells in a dose-dependent manner. LN229 and T98G cells (5 × 103) were treated with 5–20 μM scriptaid for 24 hrs, and cells were subjected to MTS assay. The graph represents decrease in glioma cell proliferation upon treatment with increasing concentration of scriptaid. (B) Fold increase in caspase-3 activity in LN229 and T98G cells treated with different concentrations of scriptaid for 24 hrs, as determined by the caspase-3 activity assay. Values in (A) and (B) represent the means ± SEM from three independent experiments. *Significant decrease/increase from control (P≤ 0.05).