Table 1.
Association of HLA-G expression in HCC lesions with clinicopathological parameters
| Variables | No. of cases | HLA-G expression | P* | ||||
|---|---|---|---|---|---|---|---|
| Negative (%) | 1–25% | 26–50% | 51–75% | >75% | |||
| Gender | |||||||
| Male | 186 | 88 (47.3) | 16 | 13 | 22 | 47 | 0.264 |
| Female | 33 | 21 (63.6) | 0 | 2 | 2 | 8 | |
| Age | |||||||
| ≤Median (52 years) | 113 | 64 (56.6) | 11 | 10 | 6 | 22 | 0.004 |
| ≥Median | 106 | 45 (42.5) | 5 | 5 | 18 | 33 | |
| Tumour differentiation | |||||||
| I | 56 | 29 (51.8) | 5 | 4 | 3 | 15 | 0.587† |
| II | 145 | 73 (50.3) | 9 | 8 | 19 | 36 | |
| III | 18 | 7 (38.9) | 2 | 3 | 2 | 4 | |
| TNM stage | |||||||
| I | 37 | 23 (62.2) | 4 | 3 | 5 | 2 | 0.029‡ |
| II | 31 | 18 (58.1) | 3 | 5 | 4 | 1 | |
| III | 21 | 6 (28.6) | 1 | 4 | 3 | 7 | |
*
Comparison of HLA-G expression status between or among each variable using the Pearson chi-square test.
†
The overall P-value among tumour differentiation stage I, II and III is 0.587; P-values for the comparison between I and II, between I and III, between II and III are 0.575, 0.624 and 0.400, respectively.
‡
The overall P-value among TNM stage I, II and III is 0.029; P-values for the comparison between I and II, between I and III, between II and III are 0.882, 0.020 and 0.037, respectively.