1.

The consensus sequence of putative promoter region of miR-21. Conserved bases across vertebrates are shown in capitals and non-conserved bases or deletions are denoted by ‘n’. The arrow indicates the transcription start site of pri-miR-21. Conserved regions of various transcription factors are indicated by different colours. Two additional RE-1-binding elements responding to transcription factor REST are located at 7214 and 7100 bp upstream of the miR-21 transcription start site [38]. This figure is reproduced from reference 25.