1.

Effect of anti-TNFα mAb treatment on diarrhoea in HLA-B27 transgenic rats. (A) Early-treated group; (B) late-treated group; (C) follow-up of the late-treated group. Stool score was determined weekly (normal stool = 1, soft stool = 2, watery stool = 3). (A) At 11 weeks of age, both IgG2 a,k-treated and untreated B27TR reached the stool score of 3 at the 13th week. (B, C) Stool character decreased from 3 to 2, after the first week of anti-TNFα mAb treatment, and then normalized in the following weeks. Data are shown as means ± S.E.M. Filled squares, anti-TNFα treated group; open squares, IgG2a,k-treated group.