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Effects of genotype and diet on APP processing and IDE expression in the ventral posterior cortex. (A) Total protein lysates of female mice on STD were analysed with Western blotting using the APP C-terminal–specific antibody. GAPDH-normalized levels of total APP (APPtot), APP C-terminal fragments (APP CTF), and IDE in (B) female mice on STD, (C) male mice on STD, (D) female mice on TWD and (E) male mice on TWD. Mean + S.D.s are shown; n ∇ 4–6 mice/group.
