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Summary of the actions of tenascins in cancer. The centre of the figure depicts the six-armed tenascin-C (TNC) and tenascin-W (TNW) protein pointing with their arms towards processes that are influenced by their presence. Although TNC is involved in all processes depicted, including the birth of a malignant cell, proliferation, migration and EMT, angiogen-esis, metastasis and evasion from therapy, TNW was shown to affect cell migration and angiogenesis (indicated by the darker arms).
