Fig 4.

Diagram of the glycolytic pathway. Glycolysis produces two ATP molecules from one glucose molecule consumed. The expression of many of the genes coding for enzymes of the pathway are HIF-1-induced (and oncogenes-induced); including HK1/2, phosphoglucose isomerase, PFK, aldolase, PGK1, phosphoglycerate mutase, enolase, pyruvate kinase (M2-PK) and the lactate dehydrogenase-a (LDH-A). NAD⁺ recycling is of capital importance for ATP generation. Glyceraldehydes-3-phosphate dehydrogenase (GAPDH).