Table 1.
Gene expression in skeletal muscle and liver tissue of wild-type and PKC-β2 transgenic mice. Expression of genes were measured in 6-month-old male wild-type and PKC-β2 transgenic mice (n= 4–8) and liver tissue from 3-month-old male mice fed chow or high-fat diet (HFD), n= 3. Data are given as relative arbitrary units ± S.E.M. See methods for diet details and text for gene names.
| Skeletal muscle | Wild-type | PKC-β2 tg | P-value |
|---|---|---|---|
| PPAR delta/28S | 4.1 ± 0.5 | 2.7 ± 0.1 | <0.05 |
| PGC-lbeta/28S | 1.6 ± 0.06 | 0.8 ± 0.1 | <0.001 |
| HSL/28S | 3.6 ± 0.5 | 2.4 ± 0.2 | <0.01 |
| ATGL/28S | 4.9 ± 0.4 | 4.8 ± 0.1 | =0.84 |
| SREBPlc/28S | 1.4 ± 0.1 | 2.5 ± 0.2 | <0.05 |
| CD36/28S | 0.54 ± 0.05 | 0.55 ± 0.04 | 0.81 |
| ACO/28S | 0.1 ± 0.06 | 0.06 ± 0.007 | <0.01 |
| Liver | Wild-type | PKC-β2 tg | P-value |
| G6Pase/28S | 3.1 ± 0.9 | 2.1 ± 0.3 | =0.48 |
| Fetuin A/28S | 2.90 ± 0.50 | 2.60 ± 0.48 | =0.49 |
| SREBPlc/28S | 2.30 ± 1.2 | 2.3 ± 0.2 | =0.97 |
| Interleukin-6/28S | 2.0 ± 0.5 | 2.7 ± 0.4 | =0.25 |
| TNF-α/28S | 1.10 ± 0.3 | 0.78 ± 0.07 | =0.25 |
| Liver | Chow | HFD | P-value |
| G6Pase/28S | 1.38 ± 0.07 | 0.96 ± 0.04 | <0.001 |
| Fetuin A/28S | 1.36 ± 0.32 | 3.66 ± 0.73 | <0.001 |
| SREBPlc/28S | 1.7 ± 0.22 | 4.0 ± 0.93 | <0.001 |