Fig. 3.
Constitutive activation of HER2 induced the increased cell migration and VE-cadherin expression. (A) MCF-7 transfected with HER2 cDNA expressed higher levels of HER2 protein and VE-cadherin protein than the untransfected cells as analysed by Western blot analysis. (B) An increase in cell migration was observed in MCF-7HER2 cells when compared with the parental MCF-7 cells. (C) The cell migration assay showed that HER2 overexpression resulted in an increased MCF-7 cell migration rate (2.76-fold, P = 0.000) when compared with the control cells.