Table 2.

A summary of the effects of IKKγ zinc finger mutations on NF-κB activity

IKKγ mutation	Cell type	Source of cells	Stimulus	Effect on NF-κB activation	References
C417R	Dendritic cells	Patient	CD154	Decrease	[74]
			LPS	No effect
C417R or D406V	Monocytes	Patient	CD154	Decrease	[57]
			LPS	No effect
			TNFα	No effect
C417R	B cells	Patient	CD154	Decrease	[67]
ZFDa, b	Fibroblasts	Patient	TNFα	Decrease	[80]
			IL-1	Decrease
C389S/C393Sc	IKKγ-null mouse fibroblasts	Cell line	TNFα	Decrease	[80]
			IL-1	No effect
C417R, D406V or ZFD	IKKγ-null mouse B cells	Cell line	UV	Decrease	[77]
			Etoposide	Decrease
			LPS	No effect
			TNFα	No effect
C417R	IKKγ-null mouse B cells	Cell line	LPS	Slight decrease	[76]
			IL-1β	Decrease
C417R	Human monocytes	Cell line	LPS	Decrease	[75]
			TNFα	Decrease
	IKKγ-null human T cells	Cell line	TRAF2d	Decrease
			TRAF6	Decrease
C417R or ZFD	IKKγ-null human T cells	Cell line	TNFα	Decrease	[79]
C417R or D406V	IKKγ-null human T cells	Cell line	TNFα/	Decrease	[78]
			PMA/ionomycin	Decrease
C417R	IKKγ-null human T cells	Cell line	TNFα	Decrease	[76]

^aZFD, zinc finger deletion.

^bCaused by a duplication of nucleotides 1166–1178, which produced a frameshift at P393 residue and then truncated the protein after the addition of four new amino acid residues.

^cThis sequence number refers to the murine IKKγ, whereas all the other sequence numbers in this table refer to the human IKKγ.

^dTRAF, tumour necrosis factor receptor-associated factor.